생물의소재공학과

KANGWON NATIONAL UNIVERSITY

Teaching Subjects

Microbial Physiology, Microbial Pathogenesis, Predictive Microbiology

Major research areas

• Resistance mechanisms of foodborne pathogens to antibiotics
• Quorum sensing and quenching to pathogenic biofilm cells
• Food Safety Engineering

Brief description on the major research interests

항생제 내성균에 대한 내성 획득 기작의 분자생물학적 이해 항생제 내성균주인 MRSA 및 다제 내성 병원성 균주의 내성 획득 기작을 이해하기 위해 ⅰ) 미생물의 항생제 비활성 기작, ⅱ)미생물 세포 표면의 투과성 기작 (receptors), ⅲ) 항생제 펌프 기작, ⅳ) 항생제 결합자리 변화 및 ⅴ) 대사과정의 변화에 대한 연구를 수행한다.

The main goal of the current study is to characterize the antibiotic cross-resistance and multiple antibiotic resistance under environmental stress conditions, understand the mechanisms of antibiotic resistance associated with planktonic, biofilm, and VBNC, compare resistance gene expression with virulence and adherence gene expression, and evaluate the horizontal gene transfer.

Recent publications (sorted)

• Influence of bacteriophage P22 on the inflammatory mediator gene expression in chicken macrophage HD11 cells infected with Salmonella Typhimurium. FEMS Microbiology Letters. (2014) 352: 11-17.
• Effect of bacteriophage on the susceptibility, motility, invasion, and survival of Salmonella Typhimurium exposed to the simulated intestinal conditions. Archives of Microbiology. (2014) 196: 201-208.